Regulation of DNA-Dependent Processes
- Genomic DNA in both prokaryotes and eukaryotes is compacted to fit into cellular compartments. We are interested in proteins that promote such compaction, because they regulate important DNA-dependent activities such as gene expression and DNA repair.
- When a bacterial pathogen infects a host, it must thwart host defenses intended to incapacitate the invader. Efficient responses therefore promote virulence and allow the pathogen to colonize the host. We are focusing on bacterial transcription factors that respond to host-derived signals to control expression of virulence genes.
Sivapragasam, S., Ghosh, A., Kumar, S., Johnson, D. T., Grove, A. Similar solutions to a common challenge: Regulation of genes encoding Ralstonia solanacearum xanthine dehydrogenase. FEMS Microbiol. Lett. 368, fnab022 (2021)
Kumar, S., Mashkoor, M., Balamurugan, P. and Grove, A. Intricate regulation of ribosome biogenesis genes in response to mTORC1 signaling. (2021). bioRxiv