Publications

law school LSU

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2024

The landscape of RNA-binding proteins in mammalian spermatogenesis.

Li Y, Wang Y, Tan YQ, ..... Vourekas A, Guo X, Lin M, Zheng K

Science PMID: 39208083

 

2023

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

Guan Y, Gao H, Leu NA, Vourekas A, Alexiou P, Maragkakis M, Kang Z, Mourelatos Z, Liang G, Wang PJ. 

PLoS Genetics PMID: 35858571.

 

2022

Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.

Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M.

Cell Reports PMID: 35858571

 

Solid-Support Directional (SSD) RNA-Seq as a Companion Method to CLIP-Seq.

Shawky AM, Dondeti M, Mourelatos Z, Vourekas A.

Methods in Molecular Biology PMID: 35796968

 

2019

Regulation of gene expression by miR-144/451 during mouse erythropoiesis

Xu P, Palmer LE, Lechauve C, Zhao G, Yao Y, Luan J, Vourekas A, Tan H, Peng J, Scheutz J, Mourelatos Z, Wu G, Weiss MJ, Paralkar VR.

Blood PMID: 30971389

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

Pinzone MR, VanBelzen DJ, Weissman S, Bertuccio MP, Cannon L, Venanzi-Rullo E, Migueles S, Jones RB, Mota T, Joseph SB, Groen K, Pasternak AO, Hwang WT, Sherman B, Vourekas A, Nunnari G, O'Doherty U.

Nature Communications PMID: 30760706 PDF

– For his work in this paper at the Una O'Doherty lab, high school student Sam Weissman took a second place and a $175,000 prize in the Regeneron Science Talent Search, which is the top science competition for high school seniors in the US. Congrats Sam!

 

2018

Set phasers to cleave: PIWI cleavage directs all piRNA biogenesis

Vourekas A, Mourelatos Z.

Molecular Cell PMID: 30193093 PDF

 

cCLIP-Seq: Retrieval of chimeric reads from HITS-CLIP (CLIP-Seq) libraries

Alexiou P*, Maragkakis M, Mourelatos Z, Vourekas A*.

Methods in Molecular Biology PMID: 29030843 PDF

*equal contribution – corresponding authors

 

2017

Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2

Fayngerts SA, Wang Z, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH.

Nature Immunology PMID: 29058702 PDF

 

2016

Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm

Vourekas A*, Alexiou P*, Vrettos N, Maragkakis M, Mourelatos Z.

Nature PMID: 26950602 PDF

*equal contribution

– Our paper was highlighted by Dr. Ekaterina Voronina in: mRNAs hit a Sticky Wicket, Developmental Cell

 

2015

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing

Vourekas A*, Zheng K*, Fu Q*, Maragkakis M*, Alexiou P, Ma J, Pillai R, Mourelatos Z, Wang PJ.

Genes & Development PMID: 25762440 PDF

*equal contribution

 

2014

TIPE3 is the transfer protein of lipid second messengers that promote cancer

Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH.

Cancer Cell PMID: 25242044 PDF

– Our paper was highlighted by Drs Moniz and Vanhaesebroeck in: A New TIPE of Phosphoinositide Regulator in Cancer, Cancer Cell

 

On the role of the appended P19 element in type A RNAs of bacterial RNase P

Stamatopoulou V, Toumpeki C, Vourekas A, Bikou M, Tsitlaidou M, Tzakos AG, Afendra A, Drainas C, Drainas D.

Biochemistry PMID: 24580115 PDF

 

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets

Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Choi I, Vourekas A, Won KJ, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH.

Cell Metabolism PMID: 24374217 PDF

 

Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver

Schug J, McKenna LB, Walton G, Hand N, Mukherjee S, Essuman K, Shi Z, Gao Y, Markley K, Nakagawa M, Kameswaran V, Vourekas A, Friedman JR, Kaestner KH, Greenbaum LE.

BMC Genomics PMID: 23597149 PDF

 

2013

HITS-CLIP (CLIP-Seq) for mouse Piwi proteins

Vourekas A, Mourelatos Z.

Methods in Molecular Biology PMID: 24178558 PDF

 

2012

Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis

Vourekas A, Zheng Q, Alexiou P, Maragkakis M, Kirino Y, Gregory BD, Mourelatos Z.

Nature Structural & Molecular Biology PMID: 22842725 PDF

– Our paper made it to the cover of the August 2012 NSMB issue

 

2011

Immunoprecipitation of piRNPs and directional, next generation sequencing of piRNAs

Kirino Y, Vourekas A, Khandros E, Mourelatos Z.

Methods in Molecular Biology PMID: 21528460 PDF

 

2010

Domain architecture of the DRpp29 protein and its interaction with the RNA subunit of Dictyostelium discoideum RNase P.

Stamatopoulou V, Toumpeki C, Tzakos A, Vourekas A*, Drainas D*.

Biochemistry PMID: 21087028 PDF

*corresponding author

 

Elective affinities: a Tudor-Aubergine tale of germline partnership.

Vourekas A, Kirino Y, Mourelatos Z.

Genes & Development PMID: 25762440 PDF

 

MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function

McKenna LB, Schug J, Vourekas A, McKenna JB, Bramswig NC, Friedman JR, Kaestner KH.

Gastroenterology PMID: 20659473 PDF

 

Arginine methylation of vasa protein is conserved across phyla

Kirino Y, Vourekas A, Kim N, de Lima Alves F, Rappsilber J, Klein PS, Jongens TA, Mourelatos Z.

Journal of Biological Chemistry PMID: 20080973 PDF

 

Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization

Kirino Y, Vourekas A, Sayed N, de Lima Alves F, Thomson T, Lasko P, Rappsilber J, Jongens TA, Mourelatos Z.

RNA PMID: 19926723 PDF

– Our paper made it to the cover of the January 2010 RNA issue

 

2009

Partial purification and characterization of RNase P from human peripheral lymphocytes

Vourekas A, Vryzaki E, Toumpeki C, Stamatopoulou V, Monastirli A, Tsambaos D, Drainas D.

Experimental Dermatology PMID: 18637127 PDF

 

2008

Insights into functional modulation of catalytic RNA activity

Vourekas A, Stamatopoulou V, Toumpeki C, Tsitlaidou M, Drainas D.

IUBMB Life PMID: 18636557 PDF

 

Activation of bacterial Ribonuclease P by macrolides

Toumpeki C, Vourekas A, Kalavrizioti D, Stamatopoulou V, Drainas D.

Biochemistry PMID: 18330998 PDF

 

2007

DRpp20 and DRpp40: two protein subunits involved in Dictyostelium discoideum ribonuclease P holoenzyme assembly

Kalavrizioti D, Vourekas A, Drainas D.

Gene PMID: 17611045 PDF

 

A 40.7 kDa Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme

Vourekas A, Kalavrizioti D, Zarkadis IK, Spyroulias GA, Stathopoulos C, Drainas D.

Biochimie. PMID: 17207566 PDF

 

Isolation of ribonuclease P activity from human epidermis and its regulation by retinoids in vitro

Pavlidou D, Vourekas A, Monastirli A, Kalavrizioti D, Tsambaos D, Drainas D.

Acta Dermatologica Venereologica PMID: 16648912 PDF

 

Hsp27 expression coincides with epidermal stratification during human epidermal morphogenesis

Monastirli A, Vourekas A, Badavanis G, Pasmatzi E, Sagriotis A, Drainas D, Pavlidou D, Georgiou S, Sakkis T, Mantagos S, Kourounis G, Varakis J, Stamatiou G, Tsambaos D.

Acta Dermatologica Venereologica PMID: 16159728 PDF

 

2006

Modulation of catalytic RNA biological activity by small molecule effectors

Vourekas A, Kalavrizioti D, Stathopoulos C, Drainas D.

Mini Reviews in Medicinal Chemistry PMID: 17017996 PDF

 

RNA-mediated therapeutics: from gene inactivation to clinical application

Kalavrizioti D*, Vourekas A*, Stamatopoulou V, Toumpeki C, Giannouli S, Stathopoulos C, Drainas D.

Current Topics in Medicinal Chemistry PMID: 17017954 PDF

*equal contribution

 

2003

Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors. Effect of antibiotics on RNase P

Kalavrizioti D, Vourekas A, Tekos A, Tsagla A, Stathopoulos C, Drainas D.

Molecular Biology Reports PMID: 12688530 PDF