BIOL 4132 - Eukaryotic Molecular Genetics

 

BIOL 4132 Fall 2024
Eukaryotic Molecular Genetics
Tuesday and Thursday, 15:00-16:20, 208 Williams Hall

Office hours, by Zoom or at my office: Tuesday 16:20-17:00 (right after class), Friday 09:00-10:20, or by appointment

How do we go from a finite sequence of approximately (2x) 3 billion letters to a being of almost limitless potential? Why sequencing a genome is not enough for us to understand its function?

In this course we study the function of the eukaryotic genome, in principle how the expression of genes is regulated at the molecular level. Regulation of gene expression is an essential characteristic of life. Developmental programming and differentiation, cellular stress (i.e. nutrient deprivation, temperature), disease, all these compel the cells to change their patterns of gene expression, either temporary or permanently, to maintain viability and grow. At the same time, recent advancements in research and applied technologies have radically increased the depth at which these phenomena can be understood, and how this knowledge can be applied to improve the human condition.

Throughout this course we are frequently focusing on particular research studies that put forward breakthrough discoveries, and the methodological advancements that allowed these discoveries. My goal is that by the end of this course, you will not only achieve a deeper understanding of the how genomic information is enacted, but you will also be inspired and realize the responsibility that we carry, especially as biologists, now that we have ability to edit (our) genomes.