Publications

Pubmed | Google Scholar 

2024

Taylor AL, Dubuisson O, Pandey P, Zunica ERM, Vandanmagsar B, Dantas  WS, Johnson AE, Axelrod CL, Kirwan JP. Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster. Aging Cell. DOI: https://doi.org/10.1111/acel.14107

2023

Villalobos TV#, Ghosh B#, DeLeo KR#, Alam S#, Ricaurte-Perez C, Wang A, Mercola BM, Butsch TJ, Ramos CD, Das S, Eymard ED, Bohnert KA* and Johnson AE*. 2023. Tubular lysosome induction couples animal starvation to healthy aging. Nature Aging  3: 1091–1106.     

#equal contributions, *corresponding authors

 

Pandey P, Wall PK, Lopez SR, Dubuisson OS, Zunica ERM, Dantas WS, Kirwan JP, Axelrod CL, and Johnson AE. A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila. BioRxiv [preprint]. DOI: https://doi.org/10.1101/2023.04.25.538137 

 

Butsch TJ, Dubuisson O., Johnson AE, Bohnert KA. 2023. VCP acts downstream of tTAFs to downregulate ubiquitinated H2A and promote spermatocyte differentiation in Drosophila. Development  150(14):dev201557

 

Butsch TJ, Johnson AE*, Bohnert KA*. 2023. Rbp4-Gal4, a germline driver that activates in meiosis, reveals functions for VCP in spermatid development. Fly 17(1):2234795. doi: 10.1080/19336934.2023.2234795. *corresponding authors

2022

Ramos CD, Bohnert KA* and Johnson AE*. 2022. Reproductive tradeoffs govern sexually dimorphic tubular lysosome induction in Caenorhabditis elegans. J Exp Biol 225 (12): jeb244282.  *corresponding authors

 

Butsch TJ, Dubuisson O, Johnson AE and Bohnert KA. 2022. A meiotic switch in lysosome activity supports spermatocyte development in young flies but collapses with age. iScience. DOI: https://doi.org/10.1016/j.isci.2022.104382

 

Bohnert KA* and Johnson AE*. 2022. Branching Off: New Insight Into Lysosomes as Tubular Organelles. Front Cell Dev Biol (review) 10:863922. *corresponding authors.

 

Dolese D, Junot M, Ghosh B, Butsch TJ, Johnson AE and Bohnert KA. 2022. Degradative tubular lysosomes links pexophagy to starvation and early aging in C. elegans. Autophagy 18(7):1522-1533.

2021

Wall JM#, Basu A#, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL and Johnson AE. 2021. CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Disease Models and Mechanisms 14 (7): dmm048603. #equal contributions

 

Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL & Davis GW. 2021. SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan. Nature Communications 12, 513. 

Pre-LSU publications:

Johnson AE, Shu H, Hauswirth AG, Tong A, Davis GW. 2015. VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. eLife. 4:e07366.

Jones CM, Chen JS, Johnson AE, Elmore ZC, Cullati SN, Beckley JR, Gould KL. 2018. Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization. Mol Biol Cell. 29(18):2176-2189.

Rachfall N, Johnson AE, Mehta S, Chen JS, Gould KL. 2014. Cdk1 Promotes Cytokinesis in Fission Yeast through Activation of the Septation Initiation Network. Mol Biol Cell. 25(15):2250-9.

Johnson AE, Chen JS, Gould KL. 2013. CK1 is required for a mitotic checkpoint that delays cytokinesis. Curr Biol. 23(19):1920-6.

Johnson AE, McCollum D, Gould KL. 2012. Polar opposites: fine-tuning cytokinesis through SIN asymmetry. Cytoskeleton (review) 69(10):686-99.

Wang Y*, Li WZ*, Johnson AE*, Luo ZQ, Sun XL, Feoktistova A, McDonald WH, McLeod I, Yates JR 3rd, Gould KL, McCollum D, Jin QW. 2012. Dnt1 Acts as a Mitotic Inhibitor of the Spindle Checkpoint Protein Dma1 in Fission Yeast. Mol Biol Cell. 23(17):3348-56. *Equal contributions.

Johnson AE, Collier SE, Ohi MD, Gould KL. 2012. Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function. J Biol Chem. 287(31): 25741-25748.

Johnson AE*, Le IP*, Andresen BT*, Stodola J, Dewey GL, Dean SB, Resau J, Haak P, Ruch T, Sartor A, Lazdins I, Barney CC, Burnatowska-Hledin MA. 2012. VACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations. Cell Tissue Res. 349(2):527-39. *Equal contributions.

Johnson AE, Gould KL. 2011. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase. EMBO J. 30(2):341-54.

Lewis SP, Willis AN, Johnson AE, Resau J, Burnatowska-Hledin MA. 2011. Mutational analysis of VACM-1/cul5 exons in cancer cell lines. APMIS. 119(7):421-30.

Lubbers J, Lewis S, Harper E, Hledin MP, Marquez GA, Johnson AE, Graves DR, Burnatowska-Hledin MA. 2011. Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells. Cell Biol Toxicol. 27(2):95-105.

Kouranti I, McLean JR, Feoktistova A, Liang P, Johnson AE, Roberts-Galbraith RH, Gould KL. 2010. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol. 8(9).

Bradley SE*, Johnson AE*, Le IP, Oosterhouse E, Hledin MP, Marquez GA, Burnatowska-Hledin M. 2010. Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect. J Biol Chem. 285(7):4883-95. *Equal contributions.

Buckwalter AL, Van Dort C, Schultz S, Smith R, Le IP, Abbot JL, Oosterhouse E, Johnson AE, Hansen-Smith F, Burnatowska-Hledin M. 2008. Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype. Microvasc Res 75(2): 155-168.

Johnson AE, Le IP, Buchwalter AL and Burnatowska-Hledin M. 2007. Estrogen Dependent Growth and Estrogen Receptor (ER)-alpha concentration in T47D Breast Cancer Cells are Inhibited by VACM-1, a cul-5 Gene. Mol Cell Biochem. 301(1-2):13-20.