Publications

Journal articles

  1. Rego BV, Murtada SI, Li G, Tellides G, Humphrey JD. "Multiscale insights into postnatal aortic development." Biomechanics and Modeling in Mechanobiology. 2024 Apr 01;23(2):687-701.
  2. Machaidze Z, D'Amore A, Freitas RCC, Joyce AJ, Bayoumi A, Rich K, Brown DW, Aikawa E, Wagner WR, Rego BV, Mayer JE. "Tissue formation and host remodeling of an elastomeric biodegradable scaffold in an ovine pulmonary leaflet replacement model." Journal of Biomedical Materials Research Part A. 2024 Feb 01;112(2):276-287.
  3. Rego BV, Weiss D, Humphrey JD. "A fast, robust method for quantitative assessment of collagen fibril architecture from transmission electron micrographs." Microscopy and Microanalysis. 2023 Dec 01;29(6):2099-2107.
  4. Weiss D, Rego BV, Cavinato C, Li DS, Kawamura Y, Emuna N, Humphrey JD. "Effects of age, sex, and extracellular matrix integrity on aortic dilatation and rupture in a mouse model of Marfan syndrome." Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Sep 01;43(9):e358–e372.
  5. Rego BV, Khalighi AH, Gorman JH, Gorman RC, Sacks MS. "Simulation of mitral valve plasticity in response to myocardial infarction." Annals of Biomedical Engineering. 2023 Jan 01;51(1):71-87. 
  6. Rego BV, Khalighi AH, Lai EK, Gorman RC, Gorman JH, Sacks MS. "In vivo assessment of mitral valve leaflet remodelling following myocardial infarction." Scientific Reports. 2022 Oct 26;12:18012. 
  7. Goswami S,* Li DS,* Rego BV, Latorre M, Humphrey JD, Karniadakis GE. "Neural operator learning of heterogeneous mechanobiological insults contributing to aortic aneurysms." Journal of the Royal Society Interface. 2022 Aug 31;19(193):20220410. *These authors contributed equally. 
  8. McGregor GL, Rego BV, Diller KR. "Mathematical model for combined effects of temperature and pressure in causing soft tissue injury." Journal of Heat Transfer. 2022 Feb 14;144(3):031001. 
  9. Yin M, Ban E, Rego BV, Zhang E, Cavinato C, Humphrey JD, Karniadakis GE. "Simulating progressive intramural damage leading to aortic dissection using DeepONet: an operator–regression neural network." Journal of the Royal Society Interface. 2022 Feb 09;19(187):20210670. 
  10. Rego BV, Pouch AM, Gorman JH, Gorman RC, Sacks MS. "Patient-specific quantification of normal and bicuspid aortic valve leaflet deformations from clinically derived images." Annals of Biomedical Engineering. 2022 Jan 07;50(1):1-15. 
  11. Estrada AC, Irons L, Rego BV, Li G, Tellides G, Humphrey JD. "Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions." PLOS Computational Biology. 2021 Dec 13;17(12):e1009683. 
  12. Rego BV, Weiss D, Bersi MR, Humphrey JD. "Uncertainty quantification in subject-specific estimation of local vessel mechanical properties." International Journal for Numerical Methods in Biomedical Engineering. 2021 Oct 04;37(12):e3535. 
  13. Weiss D,* Latorre M,* Rego BV, Cavinato C, Tanski BJ, Berman AG, Goergen CJ, Humphrey JD. "Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement." Acta Biomaterialia. 2021 Jul 29;134:422-434. *These authors contributed equally. 
  14. Narang H, Rego BV, Khalighi AH, Aly A, Pouch AM, Gorman RC, Gorman JH, Sacks MS. "Pre-surgical prediction of ischemic mitral regurgitation recurrence using in vivo mitral valve leaflet strains." Annals of Biomedical Engineering. 2021 Apr 09;49(12):3711-3723. 
  15. Castillero E, Howsmon DP, Rego BV, Keeney S, Driesbaugh KH, Kawashima T, Xue Y, Camillo C, George I, Gorman RC, Gorman JH, Sacks MS, Levy RJ, Ferrari G. "Altered responsiveness to TGFβ and BMP and increased CD45+ cell presence in mitral valves are unique features of ischemic mitral regurgitation." Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Apr 08;41(6):2049-2062. 
  16. Howsmon DP,* Rego BV,* Castillero E, Ayoub S, Khalighi AH, Gorman RC, Gorman JH, Ferrari G, Sacks MS. "Mitral valve leaflet response to ischaemic mitral regurgitation: from gene expression to tissue remodelling." Journal of the Royal Society Interface. 2020 May 06;17(166):20200098. *These authors contributed equally. 
  17. Sacks MS, Drach A, Lee CH, Khalighi AH, Rego BV, Zhang W, Ayoub S, Yoganathan AP, Gorman RC, Gorman JH. "On the simulation of mitral valve function in health, disease, and treatment." Journal of Biomechanical Engineering. 2019 Jul 01;141(7):070804. 
  18. Khalighi AH, Rego BV, Drach A, Gorman RC, Gorman JH, Sacks MS. "Development of a functionally equivalent model of the mitral valve chordae tendineae through topology optimization." Annals of Biomedical Engineering. 2019 Jan 15;47(1):60-74. 
  19. Rego BV, Khalighi AH, Drach A, Lai EK, Pouch AM, Gorman RC, Gorman JH, Sacks MS. "A noninvasive method for the determination of in vivo mitral valve leaflet strains." International Journal for Numerical Methods in Biomedical Engineering. 2018 Dec 04;34(12):e3142.
  20. Sacks MS, Khalighi A, Rego B, Ayoub S, Drach A. "On the need for multi-scale geometric modelling of the mitral heart valve." Healthcare Technology Letters. 2017 Oct 25;4(5):150. 
  21. Rego BV, Sacks MS. "A functionally graded material model for the transmural stress distribution of the aortic valve leaflet." Journal of Biomechanics. 2017 Mar 21;54:88-95. 
  22. Rego BV, Wells SM, Lee CH, Sacks MS. "Mitral valve leaflet remodelling during pregnancy: insights into cell-mediated recovery of tissue homeostasis." Journal of the Royal Society Interface. 2016 Dec 07;13(125):20160709. 

Book chapters

  1. Khang A, Buchanan RM, Ayoub S, Rego BV, Lee CH, Sacks MS. "Biological mechanics of the heart valve interstitial cell." Advances in Heart Valve Biomechanics: Valvular Physiology, Mechanobiology, and Bioengineering. 2019 Mar 14:3-36.
  2. Rego BV, Wells SM, Lee CH, Sacks MS. "Remodelling potential of the mitral heart valve leaflet." Advances in Heart Valve Biomechanics: Valvular Physiology, Mechanobiology, and Bioengineering. 2019 Mar 14:181-206.
  3. Khalighi AH, Rego BV, Drach A, Gorman RC, Gorman JH, Sacks MS. "Towards patient-specific mitral valve surgical simulations." Advances in Heart Valve Biomechanics: Valvular Physiology, Mechanobiology, and Bioengineering. 2019 Mar 14:471-487.
  4. Khang A, Buchanan RM, Ayoub S, Rego BV, Lee CH, Ferrari G, Anseth KS, Sacks MS. "Mechanobiology of the heart valve interstitial cell: simulation, experiment, and discovery." Mechanobiology in Health and Disease. 2018 Aug 01:249-283.

Published abstracts

  1. Castillero E, Howsmon DP, Rego BV, Xue Y, Gorman RC, Sacks M, Levy R, Ferrari G. "Ischemic mitral regurgitation is associated with impaired transforming growth factor/bone morphogenic protein signaling and increased CD45+ cell presence in the mitral valve interstitial cell population." Circulation. 2020 Nov 12;142(sup3):A15013. 
  2. Narang H, Rego B, Khalighi A, Aly A, Pouch A, Gorman R, Gorman JH, Sacks M. "Patient-specific analysis of pre-surgical leaflet deformations to predict outcomes of surgical repair for ischemic mitral regurgitation." Circulation. 2020 Nov 12;142(sup3):A17158. 
  3. Sacks M, Rego B, Howsmon D, Wells S. "What is the remodeling potential of the native heart valve?" Structural Heart. 2020 Feb 13;4(sup1):45. 
  4. Castillero E, Howsmon DP, Rego BV, Xue Y, Gorman RC, Sacks MS, Levy RJ, Ferrari G. "Transforming growth factor-β pathway gene expression changes in an ovine model of ischemic mitral regurgitation." Circulation. 2019 Nov 11;140(sup1):A13800.