Publications

Selected Publications Original Research Articles (as corresponding author)

  1. Ling, T., Hadi, V., Bollinger, J., Rivas, F*. Rapid access to polycyclic systems via a base-catalyzed cascade cyclization reaction. Bioorganic Chemistry 2020;99:103846. doi:10.1016/j.bioorg.2020.103846
  2. Ling T, Miller DJ, Lang WH, Griffith E, Rodriguez-Cortes A, El Ayachi I, Palacios G, Min J, Miranda-Carboni G, Lee RE, Rivas, F*. Mechanistic insight on the mode of action of colletoic acid. Med. Chem. 2019 Jul 24. doi: 10.1021/acs.jmedchem.9b00187
  3. Ling, T., Lang, W. H., Maier, J., Rivas, F*. Cytostatic and cytotoxic natural products against cancer cellular models. Molecules. 2019 May 26;24(10). pii: E2012. doi: 10.3390/molecules24102012
  4. Ling, T.; Lang, W. H.; Craig, J.; Potts, M. B.; Budhraja, A.; Opferman, J.; Bollinger, J.; Rivas, F*. Studies of Jatrogossone A from Jatropha gossypiifolia as a reactive oxygen species inducer in cancer cellular models. J Nat. Prod. 2019 May 14. doi: 10.1021/acs.jnatprod.8b01087. PMID: 31084028
  5. Ling, T.; Lang, W. H.; Martinez-Montemayor, M*.; Rivas, F*. Development of ergosterol peroxide probes for cellular localization studies. Biomol. Chem. 2019 Apr 26. doi: 10.1039/c9ob00145j. (front cover, Ed. 17).
  6. Ling, T.; Meir, J.; Das, S.; Budhraja, A.; Bassett, R.; Potts, M.; Shelat, A.; Rankovic, Z.; Opferman, J. T*.; Rivas, F*. Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents. J. Med. Chem. 164, 391-398. 2018. PMID:30611980
  7. Martínez-Montemayor*, M. M.; Ling, T.; Suárez-Arroyo, I. J.; Ortiz Soto, G.; Negrón, C. S.; Lacourt-Ventura, M. Y.; Valentín-Acevedo, A.; Lang, W. H.; Rivas, F*. Identification of biologically active Ganoderma lucidum compounds and synthesis of novel and improved derivatives that confer anti-cancer activities tested in different in vitro cancer models. Pharmacol. 10:115, 1-17, 2019.
  8. Ling, T.; Lang, W.; Feng, X.; Das, S.; Maier, J.; Jeffries, C.; Shelat, A.; Rivas, F*. Novel vitexin-inspired scaffold against leukemia. J. Med. Chem. 146, 501-510, 2018. PMID:29407975
  9. Rivas, F*.; Ling, T. All- carbon quaternary centers in natural products and medicinal chemistry: recent advancements. Tetrahedron, 72, 6729-6777, 2016.
  10. Rivas, F*.; Ling, T. Synthetic advances towards functionalized γ-lactams featuring (-)- salinosporamide A and related natural products. Org Prep and Proced Int. 3, 254-295,
  11. Gautam, L. N.; Ling, T.; Lang, W.; Rivas, F*. Anti-proliferative evaluation of monoterpene derivatives against leukemia. Eur J Med Chem., 113, 75-80, 2016.
  12. Ling, T.; Gautam, L. N.; Griffith, E.; Das, S.; Lang, W.; Shadrick, W. R.; Shelat, A.; Lee, R. E.; Rivas, F*. Synthesis and evaluation of colletoic acid core derivatives. J. Med. Chem. 110 126-132, 2016.
  13. Rivas, F*.; Palacios, G.; Ling, T.; Anderson, K.; Marino, R.; Jeffrey, C. Promising natural products against glucocorticoid resistant acute lymphoblastic leukemia. Planta Medica. 81(11):891-892, 2015.
  14. Ling, T.; Hadi, V.; Guiguemde, A.; Landfear, S. C.; Rivas, F. Identification of potential therapeutic agents from Jatropa Isabelli natural products. Recent Adv Phytochem. 45, 77-98, 2015.
  15. Ling, T.; Tran, M.; Gonzales, M. A.; Gautam, L. N.; Wood, R.; Connelly, M.; Fatima, I.; Gustavo Miranda-Carboni, G.; Rivas, F*. (+)-Dehydroabietylamine analogs target triple negative breast cancer. J. Med. Chem. 102, 9-13, 2015.
  16. González A. M.; Clark, J.; Connelly, M.; Rivas F*. Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group. Bioorg Med Chem Lett. 5234-5237, 2014.
  17. Zhai, ; Clark, J.; Connelly, M.; Ling, T.; Medina-Bolivar, F.; Rivas, F*. Antimalarial evaluation of the chemical components of the hairy root culture of bixa orellana. Molecules. 19, 756-766, 2014.
  18. Ling, T.; Griffith, E.; Mitachi, K.; Rivas, F*. Scalable and divergent total synthesis (+)-colletoic acid, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor. Org Lett. 15, 5790–5793, 2013.
  19. Hadi, V.; Hotard, M.; Ling, T.; Salinas, Y. G.; Palacios, G.; Connelly, ; Rivas, F*. Structure activity relationship of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents. Eur. J. Med. Chem. 65, 376-380, 2013.
  20. Mitachi, K.; Salinas, Y. G.; Connelly, M.; Jensen, N.; Ling, T.; Rivas, F*. Synthesis and structure-activity relationship of disubstituted benzamides as a novel class of antimalarial agents. Bioorg Med Chem. 22, 4536-4539, 2012.

Original Research Articles (as a collaborator)

  1. González-Cardenete, M. A.; Rivas, F.; Basset, R.; Stadler, M. ; Hering, S.; Padrón, J. M.; Dea-Ayuela, M. A.; Zaragozá, R. J. Synthesis and Biological Activity of Functionalized Ferruginol and Sugiol Analogues. under review.
  2. Balasubramaniam, S.; May, X.; Vijayan, S.; Goldman, L. V.; Dodson, K.; Adhikari, S.; Rivas, F.; Watkins, D.; Stoddard, S. Design and Synthesis of Diazine-based Panobinostat Analogues for HDAC8 Inhibition. Beilstein J. Org. Chem. 2020, 16, 628-637.
  3. Hamulić, D.; Stadler, M.; Hering, S.; Padrón, J. M.; Bassett, R., Rivas,; Dea-Ayuela, M. A.; González-Cardenete, M. A. First Synthesis and Biological studies of the Abietane (+)-liquiditerpenoic acid A (abietopinoic acid) and some analogues: SAR studies. J. Nat. Prod., 82 (4), 823-831, 2019.
  4. Kearney, S. E.; Zahoránszky-Kőhalmi, G.; Brimacombe, K. R.; Henderson, M. J.; Lynch, C.; Zhao, T.; Wan, K. K.; Itkin, Z.; Dillon, C.; Shen, M. ; Cheff, D. M. ; Lee, T. D. ; Bougie, D.; Cheng, K. ; Coussens, N.; Dorjsuren, D.; Eastman, R.T.; Huang, R.; Iannotti, M.; Karavadhi, S.; Klumpp-Thomas, C.; Roth, J.; Sakamuru, S.; Sun, W.; Titus, S. A.; Yasgar, A.; Zhang, Y.-Q.; Zhao, J.; Andrade, R. B.; Brown, M. K.; Burns, N. Z.; Cha, J. K.; Mevers, E. E.; Clardy, J.; Clement, J. A.; Crooks, P. A.; Cuny, G. D.; Ganor, J.; Moreno, J.; Morrill, L. A., Picazo, E.; Susick, R.B.; Garg, N. K.; Goess, B. C.; B. Grossman, R., Hughes, C.C.; Johnston, J. N.; Joullié, M.M.; Kinghorn, A. D.; Kingston, D.G.I.; Krische, M. J.; Kwon, O.; Maimone, T.J.; Majumdar, S.; Maloney, K. N.; Mohamed, E., Murphy, B.T.; Nagorny, P.; Olson, D.E., Overman, L.E.; Brown, L. E.;  Snyder, J. K.; A. Porco, Jr., J.; Rivas, F.; Ross, S. A.; Sarpong, R., Sharma, I.; Shaw, J.T.; Xu, Z.; Shen, B.; Shi, W.; Stephenson, C., Verano, A.L.; Tan, D.S.; Tang, Y.; Taylor, R. E.; Thomson, R.J.; Vosburg, D.A.; Wu, J., Wuest, W.M.; Zakarian, A.; Zhang, Y.; Ren, T.; Zuo, Z.; Inglese, J.; Michael, S.; Simeonov, A.; Zheng, W.; Shinn, P.; Jadhav, A.; Boxer, M.B.; Hall, M. D.; Xia, M.; Guha, R.; Rohde, J. M. Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space. Chemrxiv.  https://doi.org/10.26434/chemrxiv.7172369.v1 .  ACS Cent. , 4(12), 1727-1741, 2018.
  5. Stoddard, S. V.; May, X.; Rivas, F.; Dodson, K.; Vijayan, S.; Adhika, S.; Parker; K.; Watkins, D., Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8). Molecular Informatics. 37, 1800080, 2018. doi: 10.1002/minf.201800080. PMID:30369061.
  6. Fatima, I.; El-Ayachi, I.; Ling, T.; Lillo, M. A.; Krutilina, R.; Seagroves, T. N.; Radaszkiewicz, T. W.; Hutnan, M.; Bryja, V.; Krum, S. A.; Rivas, F.; Miranda-Carboni, G. A. The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. PLoS One. 12(12):e0189864, 2017.